TY - JOUR
T1 - Advancing personalized diagnosis and treatment using deep learning architecture
AU - Ullah, Rahat
AU - Sarwar, Nadeem
AU - Alatawi, Mohammed Naif
AU - Alsadhan, Abeer Abdullah
AU - Salamah Alwageed, Hathal
AU - Khan, Maqbool
AU - Ali, Aitizaz
N1 - Publisher Copyright:
Copyright © 2025 Ullah, Sarwar, Alatawi, Alsadhan, Salamah Alwageed, Khan and Ali.
PY - 2025
Y1 - 2025
N2 - Autoimmune disorders (AID) present significant challenges due to their complex etiologies and diverse clinical manifestations. Traditional diagnostic methods, which rely on symptom observation and biomarker detection, often lack specificity and fail to provide personalized treatment options. This study proposes ImmunoNet, a deep learning-based framework that integrates genetic, molecular, and clinical data to enhance the accuracy of autoimmune disease diagnosis and treatment. ImmunoNet leverages convolutional neural networks (CNNs) and multi-layer perceptrons (MLPs) to analyze large-scale datasets, enabling precise disease classification and personalized therapeutic treatment recommendations. The model improves interpretability through explainable AI techniques and enhances privacy via federated learning. Comparative evaluations demonstrate that ImmunoNet outperforms traditional machine learning models, achieving a 98% accuracy rate in predicting autoimmune disorders. By advancing precision medicine in immunology, this approach provides clinicians with a powerful tool for personalized diagnosis and optimized therapeutic strategies.
AB - Autoimmune disorders (AID) present significant challenges due to their complex etiologies and diverse clinical manifestations. Traditional diagnostic methods, which rely on symptom observation and biomarker detection, often lack specificity and fail to provide personalized treatment options. This study proposes ImmunoNet, a deep learning-based framework that integrates genetic, molecular, and clinical data to enhance the accuracy of autoimmune disease diagnosis and treatment. ImmunoNet leverages convolutional neural networks (CNNs) and multi-layer perceptrons (MLPs) to analyze large-scale datasets, enabling precise disease classification and personalized therapeutic treatment recommendations. The model improves interpretability through explainable AI techniques and enhances privacy via federated learning. Comparative evaluations demonstrate that ImmunoNet outperforms traditional machine learning models, achieving a 98% accuracy rate in predicting autoimmune disorders. By advancing precision medicine in immunology, this approach provides clinicians with a powerful tool for personalized diagnosis and optimized therapeutic strategies.
KW - CNN
KW - MLP
KW - autoimmune disorder
KW - deep learning
KW - ensemble learning
UR - https://www.scopus.com/pages/publications/105002252788
U2 - 10.3389/fmed.2025.1545528
DO - 10.3389/fmed.2025.1545528
M3 - Article
AN - SCOPUS:105002252788
SN - 2296-858X
VL - 12
JO - Frontiers in Medicine
JF - Frontiers in Medicine
M1 - 1545528
ER -