Assessment of utility of lycopene, selenium, and Vitamin e in management of oral leukoplakia

Abhigyan Manas; C. H. Venkateswararao; Shivali Vaid; Vidhi Dhakray Khanna; M. Muhaseena; Sadaf Alvi

doi:10.4103/jpbs.jpbs-63-22

Assessment of utility of lycopene, selenium, and Vitamin e in management of oral leukoplakia

Abhigyan Manas
, C. H. Venkateswararao
, Shivali Vaid^*
, Vidhi Dhakray Khanna
, M. Muhaseena
, Sadaf Alvi

^*Corresponding author for this work

Biomedical Dental Sciences Department (BDS)

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Objectives: To assess the utility of lycopene, selenium, and vitamin E in the management of leukoplakia. Materials and Methods: In this cross-sectional observational prospective study, 52 patients of oral leukoplakia were divided into 2 groups. Group I patients were prescribed 6 mg of lycopene, 400 I.U. of vitamin E, and 200 μg of selenium twice a day. Group II patients were prescribed a placebo capsule. The clinical improvement was recorded in both groups. Results: The mean pretreatment size of lesion in group I was 9.24 cm 2 and in group II was 8.52 cm 2. Post treatment size was 1.52 cm 2 in group I and 6.28 cm 2 in group II. There was a significant reduction in the size of lesion in group I compared to group II (P < 0.05). Conclusion: The treatment with a combination of lycopene, selenium, and vitamin E is useful and effective in managing the cases of oral leukoplakia.

Original language	English
Pages (from-to)	S233-S235
Journal	Journal of Pharmacy and Bioallied Sciences
Volume	14
Issue number	5
DOIs	https://doi.org/10.4103/jpbs.jpbs-63-22
State	Published - Jul 2022

Keywords

Lycopene
oral leukoplakia
selenium
vitamin E

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title = "Assessment of utility of lycopene, selenium, and Vitamin e in management of oral leukoplakia",

abstract = "Objectives: To assess the utility of lycopene, selenium, and vitamin E in the management of leukoplakia. Materials and Methods: In this cross-sectional observational prospective study, 52 patients of oral leukoplakia were divided into 2 groups. Group I patients were prescribed 6 mg of lycopene, 400 I.U. of vitamin E, and 200 μg of selenium twice a day. Group II patients were prescribed a placebo capsule. The clinical improvement was recorded in both groups. Results: The mean pretreatment size of lesion in group I was 9.24 cm 2 and in group II was 8.52 cm 2. Post treatment size was 1.52 cm 2 in group I and 6.28 cm 2 in group II. There was a significant reduction in the size of lesion in group I compared to group II (P < 0.05). Conclusion: The treatment with a combination of lycopene, selenium, and vitamin E is useful and effective in managing the cases of oral leukoplakia.",

keywords = "Lycopene, oral leukoplakia, selenium, vitamin E",

author = "Abhigyan Manas and Venkateswararao, \{C. H.\} and Shivali Vaid and \{Dhakray Khanna\}, Vidhi and M. Muhaseena and Sadaf Alvi",

year = "2022",

month = jul,

doi = "10.4103/jpbs.jpbs-63-22",

language = "English",

volume = "14",

pages = "S233--S235",

journal = "Journal of Pharmacy and Bioallied Sciences",

issn = "0975-7406",

number = "5",

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TY - JOUR

T1 - Assessment of utility of lycopene, selenium, and Vitamin e in management of oral leukoplakia

AU - Manas, Abhigyan

AU - Venkateswararao, C. H.

AU - Vaid, Shivali

AU - Dhakray Khanna, Vidhi

AU - Muhaseena, M.

AU - Alvi, Sadaf

PY - 2022/7

Y1 - 2022/7

N2 - Objectives: To assess the utility of lycopene, selenium, and vitamin E in the management of leukoplakia. Materials and Methods: In this cross-sectional observational prospective study, 52 patients of oral leukoplakia were divided into 2 groups. Group I patients were prescribed 6 mg of lycopene, 400 I.U. of vitamin E, and 200 μg of selenium twice a day. Group II patients were prescribed a placebo capsule. The clinical improvement was recorded in both groups. Results: The mean pretreatment size of lesion in group I was 9.24 cm 2 and in group II was 8.52 cm 2. Post treatment size was 1.52 cm 2 in group I and 6.28 cm 2 in group II. There was a significant reduction in the size of lesion in group I compared to group II (P < 0.05). Conclusion: The treatment with a combination of lycopene, selenium, and vitamin E is useful and effective in managing the cases of oral leukoplakia.

AB - Objectives: To assess the utility of lycopene, selenium, and vitamin E in the management of leukoplakia. Materials and Methods: In this cross-sectional observational prospective study, 52 patients of oral leukoplakia were divided into 2 groups. Group I patients were prescribed 6 mg of lycopene, 400 I.U. of vitamin E, and 200 μg of selenium twice a day. Group II patients were prescribed a placebo capsule. The clinical improvement was recorded in both groups. Results: The mean pretreatment size of lesion in group I was 9.24 cm 2 and in group II was 8.52 cm 2. Post treatment size was 1.52 cm 2 in group I and 6.28 cm 2 in group II. There was a significant reduction in the size of lesion in group I compared to group II (P < 0.05). Conclusion: The treatment with a combination of lycopene, selenium, and vitamin E is useful and effective in managing the cases of oral leukoplakia.

KW - Lycopene

KW - oral leukoplakia

KW - selenium

KW - vitamin E

UR - https://www.scopus.com/pages/publications/85135118026

U2 - 10.4103/jpbs.jpbs-63-22

DO - 10.4103/jpbs.jpbs-63-22

M3 - Article

AN - SCOPUS:85135118026

SN - 0975-7406

VL - 14

SP - S233-S235

JO - Journal of Pharmacy and Bioallied Sciences

JF - Journal of Pharmacy and Bioallied Sciences

IS - 5

ER -

Assessment of utility of lycopene, selenium, and Vitamin e in management of oral leukoplakia

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Keywords

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