Characterization, Antitumor and Antibacterial Potentials of Extracellular Pigment-Mediated Silver Nanoparticles Produced from Penicillium vinaceum AUMC 9402; Green Approach

This study aimed to a rapid, eco-friendly and low-cost method for green synthesis of pigment mediated silver nanoparticles by Penicillium vinaceum AUMC 9402 (Pp–AgNPs) as an alternative to chemical procedures. Pp–AgNPs were subjected to microscopic and spectrophotometric analysis to determine its shape and size as TEM, UV–Visible Spectrophotometer, XRD, FTIR and DLS. The TEM analysis has revealed the spherical shape of Pp–AgNPs with size ranged between 8.2 and 14.9 nm with the mean of 10.6 nm. Thermal stability of Pp–AgNPs was also studied by TGA and DSC analysis which revealed high thermal stability of theses nanoparticles. Moreover, Pp–AgNPs have been evaluated for their effect on the growth of some +ve and −ve bacterial strains as Staphylococcus aureus ATCC 6538, Bacillus subtilis NCTC 10400, Pseudomonas aeruginosa ATCC-10145 and Escherichia coli ATCC 8739. Results revealed that Pp–AgNPs significantly have inhibitory effect on the tested bacteria. Additionally, the antitumor effect of Pp–AgNPs was also studied and the results revealed that these particles can be used as a promising antitumor agent.