TY - JOUR
T1 - Clinical profile, risk factors and outcomes of ric COVID-19
T2 - A retrospective cohort multicentre study in Saudi Arabia
AU - Albuali, Waleed H.
AU - Alghamdi, Amal A.
AU - Aldossary, Shaikha J.
AU - Alharbi, Saleh A.
AU - Al Majed, Sami I.
AU - Alenizi, Ahmed
AU - Al-Qahtani, Mohammad H.
AU - Lardhi, Amer A.
AU - Al-Turki, Shams A.
AU - Alsanea, Abdulaziz S.
AU - Bubshait, Dalal K.
AU - Kobeisy, Sumayyah A.
AU - Herzallah, Noor H.
AU - Alqarni, Wejdan A.
AU - Alharbi, Abeer H.
AU - Albuali, Hamad W.
AU - Aldossary, Bader J.
AU - Alqurashi, Faisal O.
AU - Yousef, Abdullah A.
N1 - Publisher Copyright:
©
PY - 2022/3/11
Y1 - 2022/3/11
N2 - Objective To describe the risk factors, clinical profile and outcomes of COVID-19 in the paediatric population. Design Multicentre, retrospective observational study. Setting Four tertiary hospitals in Saudi Arabia. Patients We recruited 390 paediatric patients aged 0-18 years who presented from March to December 2020 and tested positive for COVID-19 on PCR. Main outcome measures We retrospectively analysed medical records for sociodemographics, health indicators, clinical presentations, laboratory findings, clinical complications, and outcomes. Results The mean participant age was 5.66±4.90 years, and the mean hospital stay was 2.17±3.48 days. Forty patients, mostly school-aged children (16, 40.00%; p=0.005) and children with comorbidities (25, 62.50%; p<0.001), received more than just supportive care. Complications were seen in 15 (3.9%) patients, bacterial infection being the most common (6, 40.00%). Patients presented with dyspnoea (OR 6.89; 95% CI 2.89 to 20.72), abnormal chest radiographs (OR 6.11; 95% CI 1.26 to 29.38), lethargy (OR 9.04; 95% CI 2.91 to 28.06) and elevated ferritin (OR 14.21; 95% CI 4.18 to 48.37) and D-dimer (OR 48.40; 95% CI 14.32 to 163.62), with higher odds of developing complications. The odds of paediatric intensive care unit (ICU) admission were higher for patients with dyspnoea (adjusted OR 4.66; 95% CI 1.24 to 17.50) and elevated white blood cell count (adjusted OR 3.54; 95% CI 1.02 to 12.30). Conclusions COVID-19 complications were limited among our patients. However, dyspnoea, abnormal chest radiographs, lethargy and elevated ferritin and D-dimer were associated with an increased risk of complications. Dyspnoea, leucocytosis, comorbidities and abnormal chest radiographs at presentation increased the risk of ICU admission.
AB - Objective To describe the risk factors, clinical profile and outcomes of COVID-19 in the paediatric population. Design Multicentre, retrospective observational study. Setting Four tertiary hospitals in Saudi Arabia. Patients We recruited 390 paediatric patients aged 0-18 years who presented from March to December 2020 and tested positive for COVID-19 on PCR. Main outcome measures We retrospectively analysed medical records for sociodemographics, health indicators, clinical presentations, laboratory findings, clinical complications, and outcomes. Results The mean participant age was 5.66±4.90 years, and the mean hospital stay was 2.17±3.48 days. Forty patients, mostly school-aged children (16, 40.00%; p=0.005) and children with comorbidities (25, 62.50%; p<0.001), received more than just supportive care. Complications were seen in 15 (3.9%) patients, bacterial infection being the most common (6, 40.00%). Patients presented with dyspnoea (OR 6.89; 95% CI 2.89 to 20.72), abnormal chest radiographs (OR 6.11; 95% CI 1.26 to 29.38), lethargy (OR 9.04; 95% CI 2.91 to 28.06) and elevated ferritin (OR 14.21; 95% CI 4.18 to 48.37) and D-dimer (OR 48.40; 95% CI 14.32 to 163.62), with higher odds of developing complications. The odds of paediatric intensive care unit (ICU) admission were higher for patients with dyspnoea (adjusted OR 4.66; 95% CI 1.24 to 17.50) and elevated white blood cell count (adjusted OR 3.54; 95% CI 1.02 to 12.30). Conclusions COVID-19 complications were limited among our patients. However, dyspnoea, abnormal chest radiographs, lethargy and elevated ferritin and D-dimer were associated with an increased risk of complications. Dyspnoea, leucocytosis, comorbidities and abnormal chest radiographs at presentation increased the risk of ICU admission.
KW - COVID-19
KW - paediatric intensive & critical care
KW - paediatrics
UR - https://www.scopus.com/pages/publications/85126389915
U2 - 10.1136/bmjopen-2021-053722
DO - 10.1136/bmjopen-2021-053722
M3 - Article
C2 - 35277403
AN - SCOPUS:85126389915
SN - 2044-6055
VL - 12
JO - BMJ Open
JF - BMJ Open
IS - 3
M1 - e053722
ER -
