TY - JOUR
T1 - Effects of anti-obesity drugs on cardiometabolic risk factors in pediatric population with obesity
T2 - a systematic review and meta-analysis of randomized controlled trials
AU - Aamir, Ahmad Bin
AU - Latif, Rabia
AU - Fallatah, Joory Osamah
AU - Alqoofi, Jood
AU - Alsalman, Hadeel Adnan
AU - Almarzoq, Fatimah Abdulkarim
N1 - Publisher Copyright:
© 2025 the author(s), published by De Gruyter, Berlin/Boston.
PY - 2025/6/1
Y1 - 2025/6/1
N2 - Following prospective registration (PROSPERO CRD42024564275), three databases (PubMed, SCOPUS, Web of Science) were searched for trials reporting the effects of anti-obesity drugs (AODs) (with placebo as control) on cardiometabolic risk factors in the pediatric population with obesity. Data was synthesized using RStudio within a Random effect model. Risk of Bias was assessed through the Cochrane Risk of Bias 2 tool. Five clinical trials fulfilled the eligibility criteria. Pooled estimates showed significant reductions in triglycerides [-13.84mg/dl (CI: -26.46 to -1.21; p 0.03) (I2 93%, p<0.01), Systolic blood pressure [-1.49mmHg (CI: -2.77 to -0.21; p 0.02) (I2 0%, p 0.61)], and Waist circumference [-6.55cm (CI: -10.56 to -2.55; p<0.01) (I2 93%, p<0.01)]. Fasting glucose, Insulin, Insulin resistance, Glycated hemoglobin, Diastolic blood pressure, Total cholesterol, Low density lipoproteins, High density lipoproteins, Very low density lipoproteins, and C-Reactive Protein showed insignificant reductions. No significant publication bias was detected in any outcome except Waist circumference (p 0.03).
AB - Following prospective registration (PROSPERO CRD42024564275), three databases (PubMed, SCOPUS, Web of Science) were searched for trials reporting the effects of anti-obesity drugs (AODs) (with placebo as control) on cardiometabolic risk factors in the pediatric population with obesity. Data was synthesized using RStudio within a Random effect model. Risk of Bias was assessed through the Cochrane Risk of Bias 2 tool. Five clinical trials fulfilled the eligibility criteria. Pooled estimates showed significant reductions in triglycerides [-13.84mg/dl (CI: -26.46 to -1.21; p 0.03) (I2 93%, p<0.01), Systolic blood pressure [-1.49mmHg (CI: -2.77 to -0.21; p 0.02) (I2 0%, p 0.61)], and Waist circumference [-6.55cm (CI: -10.56 to -2.55; p<0.01) (I2 93%, p<0.01)]. Fasting glucose, Insulin, Insulin resistance, Glycated hemoglobin, Diastolic blood pressure, Total cholesterol, Low density lipoproteins, High density lipoproteins, Very low density lipoproteins, and C-Reactive Protein showed insignificant reductions. No significant publication bias was detected in any outcome except Waist circumference (p 0.03).
KW - anti-obesity agents
KW - anti-obesity drugs
KW - pediatric obesity
KW - systolic pressure
KW - triglycerides
KW - waist circumference
UR - https://www.scopus.com/pages/publications/105007359565
U2 - 10.1515/ijamh-2024-0196
DO - 10.1515/ijamh-2024-0196
M3 - Article
C2 - 40459327
AN - SCOPUS:105007359565
SN - 0334-0139
VL - 37
SP - 141
EP - 154
JO - International Journal of Adolescent Medicine and Health
JF - International Journal of Adolescent Medicine and Health
IS - 3
ER -
