Latest trends in magnetic nanohybrids in medicines and drug delivery applications

In recent years, there has been a huge research interest in targeted cancer therapeutics using magnetic nanoparticles. The discovery of several nanocarriers based on structured silica, graphene oxides, halloysite clay nanotube, metal oxide and Janus nanoparticles with large surface area and pharmacology properties has been reported to improve the multifunctional biomedical applications. The development of magnetic nanohybrids with chemo drugs functionalization and diagnostic ability has been reported to increase the therapeutic efficiency, enhance the bioavailability and reduces the toxicity to normal cells. The chapter will overview the recent synthesis techniques of different spinel ferrite magnetic based nanohybrids involving hydrothermal, core-shell, rapid-combustion, microwave, ultrasonication, coprecipitation, enforced adsorption, and sonochemical techniques. The ability of functionalization with chemo drugs (cisplatin, doxorubicin), fluorescence and magnetic resonance properties are reported for sustained drug delivery, hyperthermia, and multimodal imaging applications. The effect of textural characteristics of nanocarrier, spinel ferrite interaction with silica and graphene oxide, effect of synthesis route for chitosan wrapping, viral extraction, and hyperthermia treatment are explored. The anticancer efficiency of different spinel ferrite magnetic/silica nanoparticles are discussed against different cancer cells.