Mitochondrial and Metabolic Adaptations to Exercise-Induced Fluid Shear Stress in Endothelial Cells

Soon Gook Hong; Junchul Shin; Maitha Aldokhayyil; Michael David Brown; Joon Young Park

doi:10.1249/JES.0000000000000289

Mitochondrial and Metabolic Adaptations to Exercise-Induced Fluid Shear Stress in Endothelial Cells

Soon Gook Hong
, Junchul Shin
, Maitha Aldokhayyil
, Michael David Brown
, Joon Young Park^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Recent studies have greatly advanced our understanding of the central role of mitochondria on endothelial function. Here, we propose a hypothesis that unidirectional laminar (pulsatile) flow and disturbed laminar (oscillatory) flow may differentially modulate mitochondrial phenotypes in the context of their bioenergetic, signaling, and biosynthetic functions, providing novel insights into subcellular mechanisms underlying how exercise benefits the improvement of vascular health.

Original language	English
Pages (from-to)	145-155
Number of pages	11
Journal	Exercise and Sport Sciences Reviews
Volume	50
Issue number	3
DOIs	https://doi.org/10.1249/JES.0000000000000289
State	Published - 1 Jul 2022
Externally published	Yes

Keywords

cell metabolism
endothelial cell
fluid shear stress
mitochondrion
mitophagy

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10.1249/JES.0000000000000289

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title = "Mitochondrial and Metabolic Adaptations to Exercise-Induced Fluid Shear Stress in Endothelial Cells",

abstract = "Recent studies have greatly advanced our understanding of the central role of mitochondria on endothelial function. Here, we propose a hypothesis that unidirectional laminar (pulsatile) flow and disturbed laminar (oscillatory) flow may differentially modulate mitochondrial phenotypes in the context of their bioenergetic, signaling, and biosynthetic functions, providing novel insights into subcellular mechanisms underlying how exercise benefits the improvement of vascular health.",

keywords = "cell metabolism, endothelial cell, fluid shear stress, mitochondrion, mitophagy",

author = "Hong, \{Soon Gook\} and Junchul Shin and Maitha Aldokhayyil and Brown, \{Michael David\} and Park, \{Joon Young\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 by the American College of Sports Medicine.",

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AU - Hong, Soon Gook

AU - Shin, Junchul

AU - Aldokhayyil, Maitha

AU - Brown, Michael David

AU - Park, Joon Young

PY - 2022/7/1

Y1 - 2022/7/1

N2 - Recent studies have greatly advanced our understanding of the central role of mitochondria on endothelial function. Here, we propose a hypothesis that unidirectional laminar (pulsatile) flow and disturbed laminar (oscillatory) flow may differentially modulate mitochondrial phenotypes in the context of their bioenergetic, signaling, and biosynthetic functions, providing novel insights into subcellular mechanisms underlying how exercise benefits the improvement of vascular health.

AB - Recent studies have greatly advanced our understanding of the central role of mitochondria on endothelial function. Here, we propose a hypothesis that unidirectional laminar (pulsatile) flow and disturbed laminar (oscillatory) flow may differentially modulate mitochondrial phenotypes in the context of their bioenergetic, signaling, and biosynthetic functions, providing novel insights into subcellular mechanisms underlying how exercise benefits the improvement of vascular health.

KW - cell metabolism

KW - endothelial cell

KW - fluid shear stress

KW - mitochondrion

KW - mitophagy

UR - https://www.scopus.com/pages/publications/85132452927

U2 - 10.1249/JES.0000000000000289

DO - 10.1249/JES.0000000000000289

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AN - SCOPUS:85132452927

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JO - Exercise and Sport Sciences Reviews

JF - Exercise and Sport Sciences Reviews

IS - 3

ER -

Mitochondrial and Metabolic Adaptations to Exercise-Induced Fluid Shear Stress in Endothelial Cells

Abstract

Keywords

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