Primary Cutaneous T-Cell/Histiocyte-Rich B-Cell Lymphoma: A Case Report and Literature Review

Sadan Mohammed Al Harbi; Nada Jomaan Al Ghamdi; Tarek Mohamed Elsharkawy; Mohammad Abdelqader Al Hamad; Sultan Bajawi

doi:10.2147/CCID.S395675

Primary Cutaneous T-Cell/Histiocyte-Rich B-Cell Lymphoma: A Case Report and Literature Review

Sadan Mohammed Al Harbi^*
, Nada Jomaan Al Ghamdi
, Tarek Mohamed Elsharkawy
, Mohammad Abdelqader Al Hamad
, Sultan Bajawi

^*Corresponding author for this work

Pathology Department

Imam Abdulrahman Bin Faisal University

Research output: Contribution to journal › Article › peer-review

Abstract

T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a lymphoproliferative disorder in which the majority of cells are reactive T cells with only a minor population of neoplastic large B cells. THRLBCL is a very rare lymphoma, and most cases are nodal THRLBCL; an extranodal case of THRLBCL presenting primarily on the skin is an extremely rare occurrence with only a few cases reported in the literature. Here, we report a case of a primary cutaneous THRLBCL in a 41-year-old Saudi male who presented unusually with multiple skin lesions. He was successfully treated with electron beam radiotherapy and had a complete resolution with no recurrence as of his 24-month follow-up.

Original language	English
Pages (from-to)	309-316
Number of pages	8
Journal	Clinical, Cosmetic and Investigational Dermatology
Volume	16
DOIs	https://doi.org/10.2147/CCID.S395675
State	Published - 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

lymphoproliferative disorder
neoplastic B cells
radiotherapy
T-cell-rich B-cell lymphoma

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10.2147/CCID.S395675

Cite this

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title = "Primary Cutaneous T-Cell/Histiocyte-Rich B-Cell Lymphoma: A Case Report and Literature Review",

abstract = "T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a lymphoproliferative disorder in which the majority of cells are reactive T cells with only a minor population of neoplastic large B cells. THRLBCL is a very rare lymphoma, and most cases are nodal THRLBCL; an extranodal case of THRLBCL presenting primarily on the skin is an extremely rare occurrence with only a few cases reported in the literature. Here, we report a case of a primary cutaneous THRLBCL in a 41-year-old Saudi male who presented unusually with multiple skin lesions. He was successfully treated with electron beam radiotherapy and had a complete resolution with no recurrence as of his 24-month follow-up.",

keywords = "lymphoproliferative disorder, neoplastic B cells, radiotherapy, T-cell-rich B-cell lymphoma",

author = "Harbi, \{Sadan Mohammed Al\} and Ghamdi, \{Nada Jomaan Al\} and Elsharkawy, \{Tarek Mohamed\} and Hamad, \{Mohammad Abdelqader Al\} and Sultan Bajawi",

note = "Publisher Copyright: {\textcopyright} 2023 Al Harbi et al.",

year = "2023",

doi = "10.2147/CCID.S395675",

language = "English",

volume = "16",

pages = "309--316",

journal = "Clinical, Cosmetic and Investigational Dermatology",

issn = "1178-7015",

}

TY - JOUR

T1 - Primary Cutaneous T-Cell/Histiocyte-Rich B-Cell Lymphoma

T2 - A Case Report and Literature Review

AU - Harbi, Sadan Mohammed Al

AU - Ghamdi, Nada Jomaan Al

AU - Elsharkawy, Tarek Mohamed

AU - Hamad, Mohammad Abdelqader Al

AU - Bajawi, Sultan

PY - 2023

Y1 - 2023

N2 - T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a lymphoproliferative disorder in which the majority of cells are reactive T cells with only a minor population of neoplastic large B cells. THRLBCL is a very rare lymphoma, and most cases are nodal THRLBCL; an extranodal case of THRLBCL presenting primarily on the skin is an extremely rare occurrence with only a few cases reported in the literature. Here, we report a case of a primary cutaneous THRLBCL in a 41-year-old Saudi male who presented unusually with multiple skin lesions. He was successfully treated with electron beam radiotherapy and had a complete resolution with no recurrence as of his 24-month follow-up.

AB - T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a lymphoproliferative disorder in which the majority of cells are reactive T cells with only a minor population of neoplastic large B cells. THRLBCL is a very rare lymphoma, and most cases are nodal THRLBCL; an extranodal case of THRLBCL presenting primarily on the skin is an extremely rare occurrence with only a few cases reported in the literature. Here, we report a case of a primary cutaneous THRLBCL in a 41-year-old Saudi male who presented unusually with multiple skin lesions. He was successfully treated with electron beam radiotherapy and had a complete resolution with no recurrence as of his 24-month follow-up.

KW - lymphoproliferative disorder

KW - neoplastic B cells

KW - radiotherapy

KW - T-cell-rich B-cell lymphoma

UR - https://www.scopus.com/pages/publications/85147452534

U2 - 10.2147/CCID.S395675

DO - 10.2147/CCID.S395675

M3 - Article

AN - SCOPUS:85147452534

SN - 1178-7015

VL - 16

SP - 309

EP - 316

JO - Clinical, Cosmetic and Investigational Dermatology

JF - Clinical, Cosmetic and Investigational Dermatology

ER -

Primary Cutaneous T-Cell/Histiocyte-Rich B-Cell Lymphoma: A Case Report and Literature Review

Abstract

UN SDGs

Keywords

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