Quantum dots encapsulated with curcumin inhibit the growth of colon cancer, breast cancer and bacterial cells

Firdos Alam Khan; Narimane Lammari; Adeeb Shezad Muhammad Siar; Khulood Mohammed Alkhater; Sarah Asiri; Sultan Akhtar; Iman Almansour; Widyan Alamoudi; Woroud Haroun; Wahida Louaer; Abdeslam Hassen Meniai; Abdelhamid Elaissari

doi:10.2217/nnm-2019-0429

Quantum dots encapsulated with curcumin inhibit the growth of colon cancer, breast cancer and bacterial cells

Firdos Alam Khan^*
, Narimane Lammari
, Adeeb Shezad Muhammad Siar
, Khulood Mohammed Alkhater
, Sarah Asiri
, Sultan Akhtar
, Iman Almansour
, Widyan Alamoudi
, Woroud Haroun
, Wahida Louaer
, Abdeslam Hassen Meniai
, Abdelhamid Elaissari

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

To synthesize and examine the impact of free Eudragit^® RS 100 nanoparticles (LN01), Quantum dots curcumin-loaded Eudragit RS 100 nanoparticles (LN04), and un-encapsulated curcumin nanoparticles (LN06) on cancerous and bacterial cells. Materials & methods: The LN01, LN04, LN06 were synthesized and characterized by Fourier transform infrared, ζ potential, UV-Vis spectroscopy, transmission electron microscopy and scanning electron microscopy and their biological activities were evaluated. Results: LN04 profoundly inhibited the growth of colon (HCT-116) cancerous cells (10.64% cell viability) and breast cancer (MCF-7) cells (10.32% cell viability) with compared to LN01 and LN06. Normal cells (HEK-293) did not show any inhibition after treatments. In addition, LN04 show better inhibitory action on bacterial growth compared with LN01 and LN06. Conclusion: We suggest that LN04 selectively target cancerous and bacterial cells and therefore possess potential anticancer and antibacterial capabilities.

Original language	English
Pages (from-to)	969-980
Number of pages	12
Journal	Nanomedicine
Volume	15
Issue number	10
DOIs	https://doi.org/10.2217/nnm-2019-0429
State	Published - Apr 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

antibacterial agent
anticancer agent
curcumin
drug delivery
quantum dots

Access to Document

10.2217/nnm-2019-0429

Cite this

@article{1c61245bdaea4f1bbe099c612278ec6a,

title = "Quantum dots encapsulated with curcumin inhibit the growth of colon cancer, breast cancer and bacterial cells",

abstract = "To synthesize and examine the impact of free Eudragit{\textregistered} RS 100 nanoparticles (LN01), Quantum dots curcumin-loaded Eudragit RS 100 nanoparticles (LN04), and un-encapsulated curcumin nanoparticles (LN06) on cancerous and bacterial cells. Materials \& methods: The LN01, LN04, LN06 were synthesized and characterized by Fourier transform infrared, ζ potential, UV-Vis spectroscopy, transmission electron microscopy and scanning electron microscopy and their biological activities were evaluated. Results: LN04 profoundly inhibited the growth of colon (HCT-116) cancerous cells (10.64\% cell viability) and breast cancer (MCF-7) cells (10.32\% cell viability) with compared to LN01 and LN06. Normal cells (HEK-293) did not show any inhibition after treatments. In addition, LN04 show better inhibitory action on bacterial growth compared with LN01 and LN06. Conclusion: We suggest that LN04 selectively target cancerous and bacterial cells and therefore possess potential anticancer and antibacterial capabilities.",

keywords = "antibacterial agent, anticancer agent, curcumin, drug delivery, quantum dots",

author = "Khan, \{Firdos Alam\} and Narimane Lammari and \{Muhammad Siar\}, \{Adeeb Shezad\} and Alkhater, \{Khulood Mohammed\} and Sarah Asiri and Sultan Akhtar and Iman Almansour and Widyan Alamoudi and Woroud Haroun and Wahida Louaer and Meniai, \{Abdeslam Hassen\} and Abdelhamid Elaissari",

note = "Publisher Copyright: {\textcopyright} 2020 {\textcopyright} 2020 Future Medicine Ltd.",

year = "2020",

month = apr,

doi = "10.2217/nnm-2019-0429",

language = "English",

volume = "15",

pages = "969--980",

journal = "Nanomedicine",

issn = "1743-5889",

number = "10",

}

TY - JOUR

T1 - Quantum dots encapsulated with curcumin inhibit the growth of colon cancer, breast cancer and bacterial cells

AU - Khan, Firdos Alam

AU - Lammari, Narimane

AU - Muhammad Siar, Adeeb Shezad

AU - Alkhater, Khulood Mohammed

AU - Asiri, Sarah

AU - Akhtar, Sultan

AU - Almansour, Iman

AU - Alamoudi, Widyan

AU - Haroun, Woroud

AU - Louaer, Wahida

AU - Meniai, Abdeslam Hassen

AU - Elaissari, Abdelhamid

PY - 2020/4

Y1 - 2020/4

N2 - To synthesize and examine the impact of free Eudragit® RS 100 nanoparticles (LN01), Quantum dots curcumin-loaded Eudragit RS 100 nanoparticles (LN04), and un-encapsulated curcumin nanoparticles (LN06) on cancerous and bacterial cells. Materials & methods: The LN01, LN04, LN06 were synthesized and characterized by Fourier transform infrared, ζ potential, UV-Vis spectroscopy, transmission electron microscopy and scanning electron microscopy and their biological activities were evaluated. Results: LN04 profoundly inhibited the growth of colon (HCT-116) cancerous cells (10.64% cell viability) and breast cancer (MCF-7) cells (10.32% cell viability) with compared to LN01 and LN06. Normal cells (HEK-293) did not show any inhibition after treatments. In addition, LN04 show better inhibitory action on bacterial growth compared with LN01 and LN06. Conclusion: We suggest that LN04 selectively target cancerous and bacterial cells and therefore possess potential anticancer and antibacterial capabilities.

AB - To synthesize and examine the impact of free Eudragit® RS 100 nanoparticles (LN01), Quantum dots curcumin-loaded Eudragit RS 100 nanoparticles (LN04), and un-encapsulated curcumin nanoparticles (LN06) on cancerous and bacterial cells. Materials & methods: The LN01, LN04, LN06 were synthesized and characterized by Fourier transform infrared, ζ potential, UV-Vis spectroscopy, transmission electron microscopy and scanning electron microscopy and their biological activities were evaluated. Results: LN04 profoundly inhibited the growth of colon (HCT-116) cancerous cells (10.64% cell viability) and breast cancer (MCF-7) cells (10.32% cell viability) with compared to LN01 and LN06. Normal cells (HEK-293) did not show any inhibition after treatments. In addition, LN04 show better inhibitory action on bacterial growth compared with LN01 and LN06. Conclusion: We suggest that LN04 selectively target cancerous and bacterial cells and therefore possess potential anticancer and antibacterial capabilities.

KW - antibacterial agent

KW - anticancer agent

KW - curcumin

KW - drug delivery

KW - quantum dots

UR - https://www.scopus.com/pages/publications/85084180641

U2 - 10.2217/nnm-2019-0429

DO - 10.2217/nnm-2019-0429

M3 - Article

C2 - 32223518

AN - SCOPUS:85084180641

SN - 1743-5889

VL - 15

SP - 969

EP - 980

JO - Nanomedicine

JF - Nanomedicine

IS - 10

ER -

Quantum dots encapsulated with curcumin inhibit the growth of colon cancer, breast cancer and bacterial cells

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this