TY - JOUR
T1 - Study of Single Nucleotide Polymorphisms Associated with Breast Cancer Patients among Arab Ancestries
AU - Osman, Yasser
AU - Elsharkawy, Tarek
AU - Hashim, Tariq Mohammad
AU - Alratroot, Jumana Abdulwahab
AU - Aljindan, Fatima
AU - Almulla, Liqa
AU - Alsuwat, Hind Saleh
AU - Al Otaibi, Waad Mohammed
AU - Hegazi, Fatma Mohammed
AU - Ibrahim, Abdallah M.
AU - Borgio, J. Francis
AU - Abdulazeez, Sayed
N1 - Publisher Copyright:
© 2022 Yasser Osman et al.
PY - 2022
Y1 - 2022
N2 - The aim of this study is to investigate the single nucleotide polymorphisms (SNPs) associated with breast cancer in our population of Arab patients. We investigated 26 breast cancer patients and an equal number of healthy age- and sex-matched control volunteers. We examined the exome wide microarray-based biomarkers and screened 243,345 SNPs for their possible significant association with our breast cancer patients. Successfully, we identified the most significant (p value ≤9.14×10-09) four associated SNPs [SNRK and SNRK-AS1-rs202018563G; BRCA2-rs2227943C; ZNF484-rs199826847C; and DCPS-rs1695739G] among persons with breast cancer versus the healthy controls even after Bonferroni corrections (p value <2.05×10-07). Although our patients' numbers were limited, the identified SNPs might shed some light on certain breast cancer-associated functional multigenic variations in Arab patients. We assert on the importance of more extensive large-scale analysis to confirm the candidate biomarkers and possible target genes of breast cancer among Arab ancestries.
AB - The aim of this study is to investigate the single nucleotide polymorphisms (SNPs) associated with breast cancer in our population of Arab patients. We investigated 26 breast cancer patients and an equal number of healthy age- and sex-matched control volunteers. We examined the exome wide microarray-based biomarkers and screened 243,345 SNPs for their possible significant association with our breast cancer patients. Successfully, we identified the most significant (p value ≤9.14×10-09) four associated SNPs [SNRK and SNRK-AS1-rs202018563G; BRCA2-rs2227943C; ZNF484-rs199826847C; and DCPS-rs1695739G] among persons with breast cancer versus the healthy controls even after Bonferroni corrections (p value <2.05×10-07). Although our patients' numbers were limited, the identified SNPs might shed some light on certain breast cancer-associated functional multigenic variations in Arab patients. We assert on the importance of more extensive large-scale analysis to confirm the candidate biomarkers and possible target genes of breast cancer among Arab ancestries.
UR - https://www.scopus.com/pages/publications/85140575644
U2 - 10.1155/2022/2442109
DO - 10.1155/2022/2442109
M3 - Article
AN - SCOPUS:85140575644
SN - 2090-3170
VL - 2022
JO - International Journal of Breast Cancer
JF - International Journal of Breast Cancer
M1 - 2442109
ER -
