Radiation-Synthesized p(ATACA/AAc) hydrogel as a biomimetic scaffold for cartilage replacement in veterinary and human orthopedics

Reem Darwesh; Sarah Alharthi; Nour E.A.Abd El-Sattar; Samera Ali Al-Gahtany; Mohamed Madani; Md Azizul Haque; Ahmed A. Zaher; Mohamed Mohamady Ghobashy

doi:10.1007/s10967-025-10628-8

Radiation-Synthesized p(ATACA/AAc) hydrogel as a biomimetic scaffold for cartilage replacement in veterinary and human orthopedics

Reem Darwesh
, Sarah Alharthi
, Nour E.A.Abd El-Sattar
, Samera Ali Al-Gahtany
, Mohamed Madani
, Md Azizul Haque^*
, Ahmed A. Zaher
, Mohamed Mohamady Ghobashy

^*Corresponding author for this work

Physics Department

King Abdulaziz University
Taif University
Ain Shams University
Alryada University for Science & Technology
University of Jeddah
Yeungnam University
Main Chemical Laboratories
Mansoura University
Egyptian Atomic Energy Authority

Research output: Contribution to journal › Article › peer-review

Abstract

Gamma irradiation (30–50 kGy) was employed to enhance the mechanical properties of novel p(ATACA/AAc) hydrogels synthesized from N-(14-Amino-3,6,9,12-tetraazatetradecyl) carbamothioyl) Acrylamide monomer. The p(ATACA/AAc) (1:1) hydrogel irradiated at 50 kGy demonstrated optimal cartilage-mimetic properties with a storage modulus of 2.5 MPa, 99% elastic recovery, and compressive strength exceeding 10 MPa. SEM revealed a porous microstructure suitable for tissue engineering, while BMMSC assays confirmed excellent biocompatibility with robust cell attachment and chondrogenic differentiation. These gamma-irradiated hydrogels represent promising candidates for cartilage tissue engineering applications.

Original language	English
Pages (from-to)	1453-1465
Number of pages	13
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	335
Issue number	2
DOIs	https://doi.org/10.1007/s10967-025-10628-8
State	Published - Feb 2026

Keywords

Acrylic acid
Cartilage
Gamma irradiation
Hydrogel

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10.1007/s10967-025-10628-8

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Darwesh, R., Alharthi, S., El-Sattar, N. E. A. A., Al-Gahtany, S. A., Madani, M., Haque, M. A., Zaher, A. A., & Ghobashy, M. M. (2026). Radiation-Synthesized p(ATACA/AAc) hydrogel as a biomimetic scaffold for cartilage replacement in veterinary and human orthopedics. Journal of Radioanalytical and Nuclear Chemistry, 335(2), 1453-1465. https://doi.org/10.1007/s10967-025-10628-8

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abstract = "Gamma irradiation (30–50 kGy) was employed to enhance the mechanical properties of novel p(ATACA/AAc) hydrogels synthesized from N-(14-Amino-3,6,9,12-tetraazatetradecyl) carbamothioyl) Acrylamide monomer. The p(ATACA/AAc) (1:1) hydrogel irradiated at 50 kGy demonstrated optimal cartilage-mimetic properties with a storage modulus of 2.5 MPa, 99\% elastic recovery, and compressive strength exceeding 10 MPa. SEM revealed a porous microstructure suitable for tissue engineering, while BMMSC assays confirmed excellent biocompatibility with robust cell attachment and chondrogenic differentiation. These gamma-irradiated hydrogels represent promising candidates for cartilage tissue engineering applications.",

keywords = "Acrylic acid, Cartilage, Gamma irradiation, Hydrogel",

author = "Reem Darwesh and Sarah Alharthi and El-Sattar, \{Nour E.A.Abd\} and Al-Gahtany, \{Samera Ali\} and Mohamed Madani and Haque, \{Md Azizul\} and Zaher, \{Ahmed A.\} and Ghobashy, \{Mohamed Mohamady\}",

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doi = "10.1007/s10967-025-10628-8",

language = "English",

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AU - Darwesh, Reem

AU - Alharthi, Sarah

AU - El-Sattar, Nour E.A.Abd

AU - Al-Gahtany, Samera Ali

AU - Madani, Mohamed

AU - Haque, Md Azizul

AU - Zaher, Ahmed A.

AU - Ghobashy, Mohamed Mohamady

N1 - Publisher Copyright: © Akadémiai Kiadó Zrt 2026.

PY - 2026/2

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AB - Gamma irradiation (30–50 kGy) was employed to enhance the mechanical properties of novel p(ATACA/AAc) hydrogels synthesized from N-(14-Amino-3,6,9,12-tetraazatetradecyl) carbamothioyl) Acrylamide monomer. The p(ATACA/AAc) (1:1) hydrogel irradiated at 50 kGy demonstrated optimal cartilage-mimetic properties with a storage modulus of 2.5 MPa, 99% elastic recovery, and compressive strength exceeding 10 MPa. SEM revealed a porous microstructure suitable for tissue engineering, while BMMSC assays confirmed excellent biocompatibility with robust cell attachment and chondrogenic differentiation. These gamma-irradiated hydrogels represent promising candidates for cartilage tissue engineering applications.

KW - Acrylic acid

KW - Cartilage

KW - Gamma irradiation

KW - Hydrogel

UR - https://www.scopus.com/pages/publications/105030673570

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VL - 335

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JO - Journal of Radioanalytical and Nuclear Chemistry

JF - Journal of Radioanalytical and Nuclear Chemistry

IS - 2

ER -

Radiation-Synthesized p(ATACA/AAc) hydrogel as a biomimetic scaffold for cartilage replacement in veterinary and human orthopedics

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